产品货号：
Z27018
中文名称：
SNAP23抗体
英文名称：
Anti-SNAP23 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-SNAP23 Antibody |
| 指标别名 | HsT17016;SNAP 23;SNAP23;SNAP23A;SNAP23B |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,IHC-F,ICC/IF,FCM |
| 基因名称 | SNAP23 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human SNAP23(192-211aa DTNRDRIDIANARAKKLIDS),different from the related rat and mouse sequences by three amino acids. |
| 实际分子量 | 23KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | SNAP23(Synaptosomal-Associated Protein,23-KD),also called SNAP23A,is a protein that in humans is encoded by the SNAP23 gene.The SNAP23 gene has 8 exons,with the initiation codon located in exon 2.The SNAP23 gene is mapped on 15q15.1-q15.2.The SNAP23 cDNA encodes a 211-amino acid polypeptide with a predicted mass of 23kD.Its amino acid sequence is 59% identical to that of SNAP25.Northern blot analysis revealed that SNAP23 is ubiquitously expressed.SNAP23 is able to bind to multiple syntaxins as well as to multiple vesicle-associated membrane proteins.After relocation,SNAP23 is required for exocytosis,implying a crucial role in promoting membrane fusion.TIVAMP-containing vesicles were concentrated in the apical domain of epithelial cells.STX3A and SNAP23 were codistributed at the apical plasma membrane,where they formed N-ethyl maleimide-dependent SNARE complexes with TIVAMP and cellubrevin.SNAP23 is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs.It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. |
| Uniprot ID | O00161 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | synaptosomal-associated protein,23kDa |
| 蛋白名全称 | Synaptosomal-associated protein 23(SNAP-23) |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunohistochemistry in frozen section (IHC-F) 1:50～400 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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